Calnexin has also been implicated in influencing Ca 2+ regulation, ,, , cell-cell adhesion, phagocytosis, and cell sensitivity to apoptosis. Calnexin, together with calreticulin, constitute the calnexin/calreticulin cycle responsible for the folding and quality control of newly-synthesized (glyco)proteins. The ER luminal domain of calnexin is responsible for lectin-like activity and interaction with nascent polypeptide chains. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.Ĭalnexin is a type I endoplasmic reticulum (ER) integral membrane protein with a single transmembrane helix followed by a cytoplasmic negatively charged C-terminal tail. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The first author has been supported (partially) by a combined fellowship from the Heart and Stroke Foundation of Canada and AstraZeneca. H-DL was supported by a postdoctoral fellowship from the Alberta Innovates-Health Solutions, Heart and Stroke Foundation of Canada and AstraZeneca. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: This work was supported by a grant from the Canadian Institutes of Health Research (MOP-15291). Received: NovemAccepted: JPublished: July 1, 2011Ĭopyright: © 2011 Li et al. Gisou van der Goot, Ecole Polytechnique Federale de Lausanne, Switzerland Citation: Li H-D, Liu W-X, Michalak M (2011) Enhanced Clathrin-Dependent Endocytosis in the Absence of Calnexin.
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